DEPRESSOR MECHANISM OF SYNTHETIC ACTH (50022)
نویسندگان
چکیده
منابع مشابه
Hypotriglycedemic action of synthetic ACTH.
The hypotriglycedemic action of ACTH was investigated in the hyperlipemic patients of various diseases. This effect was apparent within 30 min after intravenous injection of the hormone and lasted up to 96 hr when it was administered intramuscularly. ACTH had no effect on the serum cholesterol or phospholipid concentration. As possible causes of this effect of ACTH, fatty acids mobilization and...
متن کاملHuman corticotropin (ACTH) radioimmunoassay with synthetic 1--24 ACTH.
A corticotropin antiserum was obtained from rabbits immunized with synthetic 1--24 corticotropin conjugated with bovine serum albumin. The antiserum did not cross react with synthetic alpha-melanotropin or with synthetic beta-endorphin and had a cross reactivity of 0.23% with human beta-lipotropin. We developed a radioimmunoassay with the antiserum obtained, in which we used polyethylene glycol...
متن کاملProlonged corticotrophic action of a synthetic substituted 1-18 ACTH.
The adrenocorticotrophic effects of a synthetic corticotrophin analogue, alpha(1-18) ACTH with D-serine(1), lysine(17), and lysine amide(18) substitutions has been studied. It is effective after both intramuscular and subcutaneous administration and compared with tetracosactrin depot (Synacthen depot, Cortrosyn depot) it has a similarly prolonged time course of action-about 24 hours after 0.5 m...
متن کاملComparative investigation on the activity of a synthetic corticotrophin (18-ACTH). A clinical trial.
The effect of the administration of a synthetic peptide with corticotrophic properties (18-ACTH) on the plasma corticosteroid levels of 72 healthy volunteers was studied. The same effect is seen both after subcutaneous and intramuscular injection. Intravenous administration provokes a longer lasting influence on adrenocortical activity, especially when large doses of the peptide are given; side...
متن کاملCortisol Response in Healthy and Diseased Dogs after Stimulation with a Depot Formulation of Synthetic ACTH
BACKGROUND The ACTH stimulation test is used to evaluate the adrenocortical reserve. Recently, the availability of the synthetic ACTH formulation was limited, causing major problems in clinical practice. OBJECTIVES The objective of this study was to evaluate poststimulation peak cortisol concentrations and the duration of the stimulatory effect of a depot ACTH preparation in dogs. ANIMALS T...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1970
ISSN: 0021-5198
DOI: 10.1254/jjp.20.585